ABSTRACT
Introduction: Adjuvant radiotherapy is considered one of treatment options for treatment of locally advanced breast cancer. Thyroid gland is not considered an organ at risk in supraclavicular (SC) nodal radiation therapy (RT) for breast cancer. Objectives: Comparison the impact of 2 different RT techniques on thyroid gland; group (I) conventional two-dimensional radiotherapy of SC node and Group (II) three-dimensional conformal radiation therapy (3DCRT) planning of SC node. Method: Twenty (20) patients with breast cancer received SC RT, with evaluation of thyroid functions in both groups, including thyroid stimulating hormone and free thyroxine prior to RT and 3, 6, 9, 12, 18 and 24 months after RT. Based on each patient's dose volume histogram (DVH),total volume of thyroid and mean radiation dose of the thyroid which received radiation doses 10-50 Gy (V10-V50) were considered for statistical analysis. The median follow-up time was 20 months (range, 12-30 months). Results: of 20 patients, 5 (20%) were diagnosed with hypothyroidism (HT), 4 group (II) and 1 group (I). The median time to the development of HT was 9 months. SC node V50 in group I was lower than average in group II (Average: 2.06% versus 55.38% p<0.001).Thyroid V20 in group I was lower than average in group II (Average: 37.65% versus 50.47%, p<0.001) mean TSH in group I was lower than mean in group II (Average: 1.60 IU/L versus 3.08 IU/L, p=0.043). Conclusion: Conformal supraclavicular RT in patients with breast cancer appear to amplify the risk of HT more than conventional, however conformal radiotherapy is better than conventional radiotherapy in locoregional control
Subject(s)
Breast Neoplasms/radiotherapy , Egypt , Thyroid GlandABSTRACT
Background: Breast cancer is the most common malignancy in women in Nigeria. Women previously treated for ipsilateral breast cancer have increased risk of developing contalateral breast cancer (CBC); the chance of which increases with longer period of survival and is associated with worse prognosis. Reports from Nigeria are few on this. The aim of this study was to assess the prevalence; predisposition; presentation; and outcome of management of bilateral breast cancer (BBC) in a population; South-western Nigeria.Methods: A review of bio-data of all patients with BBC seen in LTH; Osogbo; Nigeria between 2001 and 2008 was done. Age; parity; age at menarche and first child birth; family history; duration of symptoms; tumour characteristics and exposure to cigarette; oral contraceptive pills (O.C Pills) and outcome of treatment were also assessed.Results: BBC constituted 4.6of the 256 breast cancer patients. Eight (73) were metachronous and 91were infiltrating ductal carcinoma. Patients' mean age; mean age at menarche and first child birth were 39; 14.5+3 and 22.5yrs respectively. Mean parity was 3.5 child birth; 91were premenopausal and all have menstruated for 12-31yrs. None had positive family history while only 1 and 3 had insignificant exposure to cigarette and O.C pills respectively. The mean interval between the 2 onsets was 18mths (0-68mths). 91of all tumours were advance; while 81of the first tumours were on the right. Mean duration before presentation for the first and second tumours were 261 and 111 days respectively. One patient has survived for 2 years thus far.Conclusion: The incidence of BBC was 4.26. Most patients were young and premenopausal with mostly infiltrating ductal carcinoma (NOS) and presenting with late stage disease; hence poor prognosis. Aggressive follow-up of patients with ipsilateral cancer will aid early detection of CBC
Subject(s)
Breast Neoplasms/epidemiology , Breast Neoplasms/radiotherapy , Female , Risk FactorsABSTRACT
Il s'agit d'une etude retrospective de 46 cas de cancers du sein survenus chez l'homme et colliges a l'institut du Cancer de Dakar de 1957 a 1999. L'age moyen des malades etait de 60;7 ans et la duree moyenne des symptomes etait de 37;5 mois. La repartition des malades selon la classification TNM de l' UICC revelait : 1T1; 1T2; 4T3; 40T4; 40N1; 1N2; SN3; 10M1 PUL; 8M1 OSS et 2M1 HEP. Le carcinome canalaire invasif representait 78;2 pour cent de l'ensemble des lesions histologiques. Nous avons realise 32 mastectomies dont 23 etaient associees a un curage axillaire. La chirurgie etait associe a une chimiotherapie dans 25 cas et a une radiotherapie dans 14 cas. Le traitement hormonal au Tamoxifene fut institue dans 7 cas. Le suivi moyen des malades etait de 24 mois. Le pronostic de ces cancers pourrait etre ameliore par une meilleure education et un diagnostic plus precoce
Subject(s)
Breast Neoplasms/diagnosis , Breast Neoplasms/radiotherapy , MastectomyABSTRACT
Les auteurs se sont proposes grace a une analyse retrospective des dossiers; d'etudier l'apport de la radiotherapie dans 55 cas de lesions malignes de la glande mammaire histologiquement confirmees et traitees dans le service de cancerologie-radiotherapie de l'hopital general de Yaounde sur une periode de 4 ans de 1991 a 1994 inclus. L'irradiation a ete menee dans tous les cas; grace aux rayons gamma d'une energie moyenne de 1;25 Mev du cobalt 60. Son effet curateur a ete evalue au niveau de la tumeur primitive et des ganglions regionaux dans le contexte d'un traitement radical d'une part et conservateur d'autre part. Son role antalgique a ete apprecie chez des patients presentant des metastases cancereuses douloureuses. Ses complications ainsi que les difficultes liees a son application au Cameroun ont ete recherchees puis precisees. Enfin; sur la base des differents resultats obtenus; les auteurs ont tire des conclusions et proposes des recommandations adaptees
Subject(s)
Breast Neoplasms/radiotherapyABSTRACT
La Prise en charge des cancers de sein revient a apprecier les orientations strategiques basees sur les principes suivants : - definir les facteurs de pronostic - preferer le traitement radical au traitement conservateur a defaut de la radiotherapie - savoir associer un traitement adjuvant : chimiotherapie ou hormonotherapie en fonction de l'age et de l'etat hormonal de la patiente. Une telle attitude permettra de prolonger la survie des patientes